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An altered fecal microbial profiling in rosacea patients compared to matched controls.
Journal of the Formosan Medical Association ( IF 3.2 ) Pub Date : 2020-05-20 , DOI: 10.1016/j.jfma.2020.04.034
Yi-Ju Chen , Wei-Hsiang Lee , Hsiu J. Ho , Ching-Hung Tseng , Chun-Ying Wu

Background/Purpose

Rosacea has been linked to inflammatory bowel disease and small bowel bacterial overgrowth. We aimed to investigate the fecal microbial profiling and the potential gene functions between rosacea and non-rosacea subjects.

Methods

A case-control study. Fecal microbiome and predicted genetic function inferred from high-throughput 16S ribosomal RNA sequencing were analyzed between rosacea (n = 11) and age-, gender- and body mass index-matched non-rosacea subjects (n=110). The correlation between altered microbiome as well as lifestyle and diet were also investigated.

Results

A significant reduction of fecal microbial richness was found in rosacea patients. A distinct fecal microbial community structure was demonstrated in rosacea patients. The discriminating enriched genera in rosacea patients included Rhabdochlamydia, CF231, Bifidobacterium, Sarcina, Ruminococcus, belonging to the phylum of Chlamydiae, Bacteroidetes, Actinobacteria, and Lentisphaerae. The discriminating reduced abundant genera included Lactobacillus, Megasphaerae, Acidaminococcus, Hemophilus, Roseburia, Clostridium, belong to the phylum of Firmicutes; and Citrobacter, belonging to the phylum of Proteobacteria. The distinct fecal microbial composition might be related to sulfur metabolism, cobalamin, and carbohydrate transport.

Conclusion

An altered fecal microbial richness and composition were observed in rosacea patients. The distinct microbial composition might be related to sulfur metabolism, cobalamin and carbohydrate transport.



中文翻译:

与匹配的对照组相比,酒渣鼻患者的粪便微生物分布发生了变化。

背景/目的

酒渣鼻与炎症性肠病和小肠细菌过度生长有关。我们旨在调查酒渣鼻和非酒渣鼻受试者之间的粪便微生物谱和潜在的基因功能。

方法

病例对照研究。从酒渣鼻(n = 11)与年龄,性别和体重指数匹配的非酒渣鼻受试者(n = 110)之间分析了从高通量16S核糖体RNA测序推断的粪便微生物组和预期的遗传功能。还研究了改变的微生物组以及生活方式和饮食之间的相关性。

结果

在酒渣鼻患者中发现粪便微生物丰富度显着降低。酒渣鼻患者表现出独特的粪便微生物群落结构。酒渣鼻患者中的鉴别丰富属包括横纹肌衣原体,CF231,双歧杆菌,Sarcina,Ruminococcus,属于衣原体的门,拟杆菌,放线菌扁豆。区分减少的丰富属包括乳杆菌,大球藻,酸性氨基球菌,嗜血杆菌,玫瑰菌,梭状芽胞杆菌;和柠檬酸杆菌,属于变形杆菌门。粪便微生物的独特组成可能与硫代谢,钴胺素和碳水化合物的运输有关。

结论

在酒渣鼻患者中观察到粪便微生物丰富度和组成发生变化。独特的微生物组成可能与硫代谢,钴胺素和碳水化合物的运输有关。

更新日期:2020-05-20
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