Rapid synthesis of 3-arylphthalides with a quaternary carbon center has been achieved via a cascade [4+1] cycloaddition/nucleophilic 1,4-addition of 2-carbonylcyclohexadienimines with two molecules of isocyanides. The reaction proceeded smoothly under metal-free conditions leading to the formation of multi-functionalized phthalides in moderate to good yields.

中文翻译：

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具有季碳中心的3-arylphthalides合成通过[4 + 1]无金属条件下的2-carbonylcyclohexadienimines与异氰化物环加成

通过2-羰基环己二亚胺与两个异氰酸酯分子的级联[4 + 1]环加成/亲核1,4-加成，已经实现了具有季碳中心的3-芳基邻苯二甲酸酯的快速合成。该反应在无金属条件下顺利进行，导致以中等至良好的产率形成多官能化的邻苯二甲酰亚胺。