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CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia.
International Immunopharmacology ( IF 3.943 ) Pub Date : 2020-05-20 , DOI: 10.1016/j.intimp.2020.106577
Chen Chen,Shi-Feng Chu,Qi-di Ai,Zhao Zhang,Nai-Hong Chen

BACKGROUND Chemokine-like factor 1 (CKLF1) is a chemokine increased significantly in ischemic brain poststroke. It shows chemotaxis effects on various immune cells, but the mechanisms of CKLF1 migrating neutrophils are poorly understood. Recent studies have provided evidence that CC chemokine receptor 5 (CCR5), a receptor of CKLF1, is involved in ischemic stroke. PURPOSES To investigate the effects of HIF-1α guided AAV in ischemic brain, investigating the outcome of stroke, and examining the involvement of CKLF1/CCR5 axis in recruitment of neutrophils. RESULTS HIF-1α guided AAV knocked down CKLF1 in ischemic area and alleviated brain damage of rats. CKLF1 migrated neutrophils through CCR5, worsening inflammatory responses. Akt/GSK-3β pathway may involve in CKLF1/CCR5 axis guided neutrophils chemotaxis. CONCLUSIONS CKLF1/CCR5 axis is involved in neutrophils migration of rats with transient cerebral ischemia. CKLF1/CCR5 axis may be a useful target for stroke therapy.
更新日期:2020-05-20

 

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