We previously reported higher levels of C-C chemokine ligand (CCL) 1 in the bronchoalveolar lavage (BAL) fluid (BALF) of patients with sarcoidosis than in BALF of patients with immunoglobulin G4 (IgG4)-related disease (IgG4-RD), indicating that CCL1 might act as a marker of disease activity in sarcoidosis. Notably, less invasive sampling sources are desirable, as BAL cannot always be performed due to its inherent risk. In this study, we sought to decipher the correlation between serum levels of CCL1 and clinical characteristics of sarcoidosis. Serum samples were obtained from 44 patients with clinically confirmed sarcoidosis, 14 patients with IgG4-RD, and 14 healthy controls. The clinical and radiological findings were retrospectively evaluated. Serum levels of CCL1 were measured using a sandwich enzyme-linked immunosorbent assay. Serum levels of other 17 cytokines and chemokines were measured using a MILLIPLEX® MAP KIT and Luminex® magnetic beads. Serum levels of CCL1 were significantly higher in patients with sarcoidosis than in patients with IgG4-RD and healthy controls. Serum CCL1 was positively correlated with the degree of hilar lymph node swelling on chest computed tomography and serum levels of soluble interleukin 2 receptor. Positive correlations were also observed between serum CCL1 and total cell counts, lymphocyte counts in BALF, and serum T helper 1 mediators such as IP-10 and TNF-α in patients with sarcoidosis. Serum CCL1 levels were significantly elevated in sarcoidosis and correlated with clinical parameters of the disease. In addition, serum and BALF levels of CCL1 were positively correlated in a statistically significant manner. Although further research in this field is necessary, CCL1 might have the potential to be a reliable serological marker of disease activity in sarcoidosis.

中文翻译：

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血清 CC 趋化因子配体 1 在结节病中的应用：与 IgG4 相关疾病的比较

我们之前报道了结节病患者支气管肺泡灌洗液 (BALF) 中 CC 趋化因子配体 (CCL) 1 的水平高于免疫球蛋白 G4 (IgG4) 相关疾病 (IgG4-RD) 患者的 BALF，表明CCL1 可能作为结节病疾病活动的标志物。值得注意的是，侵入性较小的采样源是可取的，因为 BAL 由于其固有的风险而不能总是执行。在这项研究中，我们试图破译 CCL1 血清水平与结节病临床特征之间的相关性。血清样本来自 44 名临床确诊结节病患者、14 名 IgG4-RD 患者和 14 名健康对照者。回顾性评估临床和放射学发现。使用夹心酶联免疫吸附测定法测量 CCL1 的血清水平。使用 MILLIPLEX® MAP KIT 和 Luminex® 磁珠测量其他 17 种细胞因子和趋化因子的血清水平。结节病患者的血清 CCL1 水平显着高于 IgG4-RD 患者和健康对照组。血清 CCL1 与胸部 CT 显示的肺门淋巴结肿胀程度和血清可溶性白细胞介素 2 受体水平呈正相关。在结节病患者的血清 CCL1 与总细胞计数、BALF 淋巴细胞计数和血清 T 辅助 1 介质如 IP-10 和 TNF-α 之间也观察到正相关。血清 CCL1 水平在结节病中显着升高，并与该疾病的临床参数相关。此外，CCL1 的血清和 BALF 水平以统计学上显着的方式呈正相关。