OBJECTIVE To study the role of laser interstitial thermal therapy in recurrent glioblastoma and to assess its effect in the overall survival and in progression-free survival. METHODS A MEDLINE and Pubmed search was performed for the key words "laser interstitial thermal therapy", "LITT" and "glioblastoma". Studies investigating overall survival and progression-free survival of recurrent glioblastoma after laser interstitial thermal therapy were selected. RESULTS A total of 17 studies met the selection criteria, accounting for 203 patients with recurrent glioblastoma who underwent 219 laser interstitial thermal therapy treatments. The median age was 57.4 years and there was male predominance (65.8 % male Vs 34.2 % female). The most common location resulted frontal lobe (29 %), followed by temporal (23.9 %), parietal (21.4 %) and occipital lobes (2.6 %). Additional locations included thalamus, corpus callosum and cerebellum (23.1 %). Pre-treatment median tumor size was 8.9 cm3. Morbidity was 6.4 % with a median hospital stay of 3.5 days. The most common complications were seizures (2%), motor deficits (1.5 %), wound infection (1.5 %), transient hemiparesis (1%) and hemorrhage (0.5 %). No deaths were reported due to LITT procedure. The median progression-free survival and the median overall survival after laser interstitial thermal therapy resulted 5.6 months and 10.2 months, respectively. The median overall survival from diagnosis was 14.7 months. All patients underwent adjuvant chemotherapy after treatment. CONCLUSION Laser interstitial thermal therapy provides an effective treatment with low morbidity for selected patients harboring recurrent glioblastoma. Laser interstitial thermal therapy should be included in the armamentarium of neurosurgical oncologist for treatment of recurrent glioblastomas.

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接受激光间质热疗 (LITT) 治疗的复发性胶质母细胞瘤患者的生存结果：系统评价

目的 研究激光间质热疗在复发性胶质母细胞瘤中的作用，并评估其对总生存期和无进展生存期的影响。方法 MEDLINE 和 Pubmed 搜索关键词“激光间质热疗”、“LITT”和“胶质母细胞瘤”。选择了调查激光间质热治疗后复发性胶质母细胞瘤的总生存期和无进展生存期的研究。结果 共有 17 项研究符合选择标准，其中 203 名复发性胶质母细胞瘤患者接受了 219 次激光间质热治疗。中位年龄为 57.4 岁，男性占优势（男性占 65.8%，女性占 34.2%）。最常见的位置是额叶 (29 %)，其次是颞叶 (23.9 %)，顶叶 (21.4%) 和枕叶 (2.6%)。其他位置包括丘脑、胼胝体和小脑 (23.1 %)。治疗前中位肿瘤大小为 8.9 cm3。发病率为 6.4%，中位住院时间为 3.5 天。最常见的并发症是癫痫发作 (2%)、运动障碍 (1.5%)、伤口感染 (1.5%)、短暂性偏瘫 (1%) 和出血 (0.5%)。没有报告因 LITT 手术造成的死亡。激光间质热治疗后的中位无进展生存期和中位总生存期分别为 5.6 个月和 10.2 个月。诊断后的中位总生存期为 14.7 个月。所有患者治疗后均接受辅助化疗。结论 激光间质热疗为选定的复发性胶质母细胞瘤患者提供了一种有效的治疗方法，发病率低。激光间质热疗法应包括在神经外科肿瘤学家的医疗设备中，用于治疗复发性胶质母细胞瘤。