Cognitive deficits mainly involving visuospatial functions have been defined in patients with bilateral and even unilateral vestibular loss (UVL). We compared the cognitive test results of 21 patients with acute UVL with age- and education-matched healthy controls. The diagnosis of UVL was based on the clinical findings, a normal magnetic resonance imaging with diffusion-weighted sequence and canal paresis on the affected side on caloric testing. Cognitive tests assessing visuospatial functions (Benton's Judgment of Line Orientation test, Verbal and non-verbal Cancellation tests, Rey-Osterrieth Complex Figure test) and global mental status, verbal memory, learning, retention of information, and recalling (Mini Mental State Examination, Oktem Verbal Memory Process Test, Forward and Backward Digit span) were used in addition to Beck depression and Anxiety inventories. Abnormalities in verbal and non-verbal cancellation tests (p < 0.005), Benton's Judgment of Line Orientation test (p = 0.042) and backward digit span (p = 0.029) was found. A very prominent difference regarding Beck depression (p = 0.012) and anxiety inventories (p < 0.001) was present. On multiple regression analysis, the abovementioned cognitive tests' results lost their statistical significance (p > 0.05) when depression and anxiety scores were taken into consideration. The severity of canal paresis was found to be correlated with Benton's Judgment of Line Orientation test (p = 0.008, r = - 0.5639) and Rey-Osterrieth Complex Figure test copying scores (p = 0.029, r = - 0.477). Comparison of all the results in right- and left-sided lesions did not reveal a significant difference (p > 0.05). Vestibular patients are prone to develop anxiety, and depression. Deficits in visuospatial functions, mental manipulation, psychomotor speed and short-term memory detected in our patients with acute UVL seem to be enhanced by accompanying anxiety and depression. The extent of vestibular dysfunction was correlated with the severity of deficits in visuospatial skills. Lesion side did not cause alterations in cognitive or emotional status.

中文翻译：

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急性单侧前庭丢失的认知功能。

在双侧甚至单侧前庭丢失（UVL）患者中已定义了主要涉及视觉空间功能的认知缺陷。我们将21例急性UVL患者与年龄和教育程度相匹配的健康对照的认知测试结果进行了比较。UVL的诊断基于临床发现，热量测试中正常的磁共振成像，扩散加权序列和患侧肛管麻痹。评估视觉空间功能的认知测试（Benton的线条定向测试，口头和非语言取消测试，Rey-Osterrieth复杂身材测试）以及整体心理状态，口头记忆，学习，信息保留和记忆力（Mini Mental State State Examination， Oktem语言记忆过程测试，除贝克抑郁和焦虑量表外，还使用了前向和后向数字跨度。语音和非语言消除测试（p <0.005），本顿线方位判断测试（p = 0.042）和后指跨度（p = 0.029）发现异常。关于贝克抑郁（p = 0.012）和焦虑量表（p <0.001）存在非常显着的差异。在多元回归分析中，当考虑抑郁和焦虑评分时，上述认知测验的结果失去了统计学意义（p> 0.05）。发现管壁轻瘫的严重程度与Benton的线方向判断测试（p = 0.008，r =-0.5639）和Rey-Osterrieth Complex Figure测试复制分数（p = 0.029，r =-0.477）相关。右侧和左侧病变中所有结果的比较未显示出显着差异（p> 0.05）。前庭患者容易出现焦虑和抑郁。在我们的急性UVL患者中发现的视觉空间功能，精神操纵，精神运动速度和短期记忆的缺陷似乎会伴随着焦虑和抑郁而加剧。前庭功能障碍的程度与视觉空间技能缺陷的严重程度相关。病变侧未引起认知或情绪状态改变。在我们的急性UVL患者中检测到的精神运动速度和短期记忆似乎通过伴随焦虑和抑郁而得到增强。前庭功能障碍的程度与视觉空间技能缺陷的严重程度相关。病变侧未引起认知或情绪状态改变。在我们的急性UVL患者中检测到的精神运动速度和短期记忆似乎通过伴随焦虑和抑郁而得到增强。前庭功能障碍的程度与视觉空间技能缺陷的严重程度相关。病变侧未引起认知或情绪状态改变。