Purpose

There are limited and inconsistent results on the correlation between vitamin D and mental health in patients with type 2 diabetes (T2D). Thus, our aim was to explore the association between vitamin D and mental well-being in a community-based sample of participants with T2D.

Methods

We analyzed serum 25-hydroxyvitamin D₃ (25(OH)D₃) in 698 patients with T2D at the baseline examination. The cohort was reinvestigated after 4 years. Data from SF-36 questionnaires measuring vitality and mental health at baseline and after 4 years were used for analyses.

Results

Serum 25(OH)D₃ was inversely associated with poor mental health at baseline (odds ratio (OR) for 10 nmol/l increase in 25(OH)D₃, 0.90 (95% confidence interval (CI) 0.83–0.96, p = 0.003)) but not at follow-up (p > 0.05). Serum 25(OH)D₃ was not associated with vitality at baseline (p > 0.05). At follow-up, there was an inverse association between 25(OH)D₃ and low vitality (OR for 10 nmol/l increase in 25(OH)D₃, 0.89 (95% CI 0.82–0.97, p = 0.009)) but not after adjustment.

Conclusion

We found an inverse association between 25(OH)D₃ and mental health in patients with T2D at baseline. We found no association between 25(OH)D₃ and vitality after adjustment. Future studies are needed to determine the association between vitamin D and mental well-being in patients with T2D.

中文翻译：

---

2型糖尿病患者的血清25（OH）D3与心理健康有关联吗？初级保健队列研究的结果。

目的

关于2型糖尿病（T2D）患者中维生素D与心理健康之间关系的研究结果有限且不一致。因此，我们的目的是在以社区为基础的T2D参与者样本中探索维生素D与心理健康之间的联系。

方法

我们在基线检查时分析了698例T2D患者的血清25-羟基维生素D ₃（25（OH）D ₃）。对该队列进行了4年的重新调查。来自SF-36问卷的数据用于分析基线和4年后的活力和心理健康。

结果

血清25（OH）d ₃呈负精神健康欠佳在基线（比值比（OR）为10纳摩尔/升增加25（OH）d相关联的₃，0.90（95％置信区间（CI）0.83-0.96，p  = 0.003）），但未随访（p  > 0.05）。血清25（OH）D ₃与基线时的生命力无关（p  > 0.05）。在随访中，25（OH）D ₃与低活力之间存在反相关关系（OR升高25（OH）D _3时每摩尔增加10 nmol ，0.89（95％CI 0.82-0.97，p  = 0.009））但调整后不会。

结论

我们发现基线时T2D患者的25（OH）D ₃与心理健康呈负相关。调整后，我们发现25（OH）D ₃与活力之间没有关联。需要进一步的研究来确定维生素D与T2D患者的心理健康之间的关联。