Imaging technologies for the analysis of the central nervous system are rapidly developing. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry imaging, tracer-based magnetic resonance imaging, CLARITY technology and optogenetics can be used to visualize small molecules in brain tissues, the interstitial system of the brain and neuronal circuits in whole-brain samples. These tools serve as powerful technical means to explore the mechanisms underlying disease models and to evaluate the effects of drugs. Here, we review the constituting principles of these imaging techniques and describe their applications in the field of neuroscience.

中文翻译：

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用于研究中枢神经系统疾病的新型成像和相关技术：综述

用于分析中枢神经系统的成像技术正在迅速发展。基质辅助激光解吸/电离飞行时间质谱成像、基于示踪剂的磁共振成像、CLARITY 技术和光遗传学可用于可视化脑组织中的小分子、大脑的间质系统和整个神经元回路。大脑样本。这些工具是探索疾病模型背后的机制和评估药物效果的有力技术手段。在这里，我们回顾了这些成像技术的构成原理，并描述了它们在神经科学领域的应用。