Anemia is commonly associated with osteoporosis and sarcopenia in older persons. However, there is a common subset of patients identified as osteosarcopenic at a higher risk of adverse outcomes. Whether these patients are also at a higher risk of anemia remains unknown. In this study, we aimed to compare hemoglobin (Hb) levels in osteosarcopenic older subjects versus those with sarcopenia, osteopenia/osteoporosis alone and controls. Cross-sectional study in 558 community-dwelling participants older than 65 (mean age 79 ± 7.5 years) from Western Sydney, Australia. Associations of anemia with sarcopenia, osteopenia/osteoporosis and osteosarcopenia were assessed. Participants were able to mobilize independently, reported a risk/history of falls and were not cognitively impaired. We used the original (EWGOP) and revised (EWGSOP2) European consensus on definition of sarcopenia, and WHO definitions of osteoporosis and osteopenia. Based on both European definitions of sarcopenia prevalence of anemia was the highest among sarcopenic patients (39%), followed by osteosarcopenic (34%), osteoporotic/penic (26%), and controls (24%). Anemia prevalence in total was 176/553 (31.5%). Osteosarcopenic patients on average had 6.3 g/L lower Hb levels compared to controls (p = 0.001), and 3.7 g/L lower Hb than patients with osteoporosis/penia (p < 0.026). Interestingly, levels of Hb did not differ between sarcopenic vs osteosarcopenic patients (p = 0.817) and between osteoporotic/osteopenic patients vs controls (p > 0.259). The higher prevalence of anemia and lower hemoglobin in sarcopenic and osteosarcopenic subjects compared to osteoporotic/penic participants and controls was established. However, the previously reported associations between osteoporosis and anemia were not confirmed. A likely explanation can be inclusion of osteosarcopenic subjects as osteoporotic in previous studies.

中文翻译：

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骨肉减少和骨少骨症老年人的血红蛋白水平较低。

贫血通常与老年人的骨质疏松症和肌肉减少症有关。但是，有一个常见的患者亚群被确定为骨少肌症，其不良结局的风险较高。这些患者是否也有更高的贫血风险尚不清楚。在这项研究中，我们旨在比较老年骨少症患者与肌肉减少症，骨质疏松症/骨质疏松症和对照组的血红蛋白（Hb）水平。对来自澳大利亚西悉尼的558位65岁以上（平均年龄79±7.5岁）的社区居民参与者进行了横断面研究。评估贫血与肌肉减少症，骨质减少/骨质疏松症和骨质减少症的关联。参与者能够独立动员，报告跌倒的风险/历史，并且没有认知障碍。我们使用了原始的（EWGOP）和修订的（EWGSOP2）欧洲关于肌肉减少症定义以及WHO的骨质疏松症和骨质减少症定义的共识。根据欧洲人对少肌症的定义，在少肌症患者中，贫血患病率最高（39％），其次是骨少肌症（34％），骨质疏松/阴茎（26％）和对照（24％）。贫血患病率总计为176/553（31.5％）。骨质疏松症患者的血红蛋白水平平均比对照组低6.3 g / L（p = 0.001），比骨质疏松症/便秘患者的Hb低3.7 g / L（p <0.026）。有趣的是，在少肌症患者和骨少症患者之间（p = 0.817）以及骨质疏松症/骨质疏松患者与对照之间（p> 0.259），Hb水平没有差异。建立了与骨质疏松/阴茎参与者和对照相比，少肌症和骨少肌症患者中贫血的患病率较高且血红蛋白较低的情况。但是，先前报道的骨质疏松症与贫血之间的关联尚未得到证实。一个可能的解释可能是在先前的研究中将骨质疏松症患者列为骨质疏松症。