Background and Objective. Rodent models of stroke impairment should capture translatable features of behavioral injury. This study characterized poststroke impairment of motor precision separately from strength in an automated behavioral assay. Methods. We measured skilled distal forelimb reach-and-grasp motions within a target force range requiring moderate-strength. We assessed whether deficits reflected an increase in errors on only one or both sides of the target force range after photothrombotic cortical stroke. Results. Pull accuracy was impaired for 6 weeks after stroke, with errors redistributing to both sides of the target range. No decrease in maximum force was measured. Conclusions. This automated reach task measures sustained loss of motor precision following cortical stroke in mice.

中文翻译：

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前肢皮质中风降低了小鼠运动控制的精度

背景和目标。中风损伤的啮齿动物模型应捕捉行为损伤的可翻译特征。这项研究在自动行为测定中将中风后运动精度受损与力量分开。方法。我们在需要中等强度的目标力范围内测量了熟练的远端前肢伸手动作。我们评估了缺陷是否反映了光血栓形成皮质中风后仅在目标力范围的一侧或两侧的错误增加。结果。中风后 6 周内拉力精度受损，误差重新分布到目标范围的两侧。未测量到最大力的降低。结论。这项自动到达任务测量小鼠皮层中风后运动精度的持续损失。