Background: Highly consistent positive associations are reported between infancy growth and later obesity risk. However, it is unclear whether infancy growth parameters beyond body weight add to the prediction of later obesity risk.Aim: To assess whether infancy length and skinfold thicknesses add to infancy weight in the prediction of childhood adiposity.Subjects and methods: This analysis included 254 children with available data on infant growth from birth to 24 months and childhood adiposity at age 6-11 years measured by DXA. Multilevel linear regression was used to examine the predictors of childhood percent body fat (%BF), with adjustment for sex and age at follow-up visit.Results: Birth weight and weight gain (modelled as changes in z-score) between 0-3 months and 3-24 months showed independent positive relationships with childhood %BF. The addition of gains in infant length and skinfolds between 0-3 months, but not 3-24 months, improved overall model prediction, from 18.7% to 20.7% of the variance in childhood %BF (likelihood ratio test, p < 0.0001), although their independent effect estimates were small (infant length gain: negative trend, partial R-square 0.6%, p = 0.2; skinfolds: positive trend, 1.3%, p = 0.09).Conclusion: Infancy length and skinfolds contribute significantly, but only modestly, to the prediction of childhood adiposity.

中文翻译：

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哪些婴儿期生长参数与后期肥胖相关？剑桥婴儿生长研究。

背景：婴儿期生长与后期肥胖风险之间存在高度一致的正相关关系。然而，目前尚不清楚体重以外的婴儿生长参数是否会增加对以后肥胖风险的预测。目的：评估婴儿身长和皮褶厚度是否会增加儿童肥胖预测中的婴儿体重。受试者和方法：该分析包括 254儿童提供从出生到 24 个月的婴儿生长情况以及通过 DXA 测量的 6-11 岁儿童肥胖情况的可用数据。使用多级线性回归来检查儿童体脂百分比 (%BF) 的预测因素，并在随访时对性别和年龄进行调整。结果：出生体重和体重增加（建模为 z 分数的变化）在 0- 3 个月和 3-24 个月与儿童 %BF 显示出独立的正相关关系。在 0-3 个月期间（而非 3-24 个月）婴儿身长和皮褶增加，改善了整体模型预测，将儿童 %BF 的方差从 18.7% 提高到 20.7%（似然比检验，p < 0.0001），尽管它们的独立效应估计很小（婴儿身长增加：负趋势，部分 R 方 0.6%，p = 0.2；皮褶：正趋势，1.3%，p = 0.09）。结论：婴儿身长和皮褶贡献显着，但仅谦虚地说，对儿童肥胖的预测。