Abstract

Two new xanthones delpyxanthone A (1) and delpyxanthone B (3), together with four known ones, gerontoxanthone I (2), α-mangostin (4), cowanin (5) and cowanol (6) were isolated from the stem bark of Garcinia delpyana. The chemical structures of 1–6 were established mainly using nuclear magnetic resonance (NMR) and mass spectrometry (MS). The anti-inflammatory activity of the isolated compounds was evaluated against lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells in vitro. Compounds 1–4 showed significant inhibitory activity against the LPS-induced NO production in RAW264.7 cells with IC₅₀ values ranging from 14.5 to 28.2 μM, but the others were inactive. The results suggested that G. delpyana and its constituents might be potential anti-inflammatory agents on RAW 264.7 cells.

摘要

从树皮的茎皮中分离出两种新的黄原酮地氧蒽醌A（1）和地氧蒽酮B（3），以及四个已知的Gerontoxanthone I（2），α-芒果素（4），Cowanin（5）和Cowanol（6）。藤黄。主要通过核磁共振（NMR）和质谱（MS）建立1–6的化学结构。评价了分离的化合物对脂多糖（LPS）诱导的RAW264.7细胞中一氧化氮（NO）产生的抗炎活性。化合物1-4显示出对LPS诱导的NO的产生在RAW264.7细胞中与IC显著抑制活性_50个值范围从14.5至28.2  μ男，但其他都是不活动的。结果表明，G。delpyana及其成分可能是对RAW 264.7细胞潜在的抗炎药。