Amyotrophic lateral sclerosis (ALS) is a motor neuron disorder, although extra‐motor degeneration is well recognized, especially in frontotemporal regions manifested as ALS with frontotemporal dementia (ALS‐FTD). Previous neuroimaging studies of the brains of ALS‐FTD patients have measured abnormalities of either grey matter (GM) or white matter (WM) structures but not of both together. Therefore, the aim was to evaluate both GM and WM in the same ALS‐FTD patient using functional and structural neuroimaging. By doing so, insights could be gained into whether neurodegeneration in ALS‐FTD is primarily a neuronopathy or axonopathy.

中文翻译：

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肌萎缩性侧索硬化症和额颞痴呆患者大脑中的2-脱氧-2- [18 F]氟-d-葡萄糖正电子发射断层扫描，皮质厚度和白质图网络异常提示早期神经元病变而非轴突病变。

肌萎缩性侧索硬化症（ALS）是一种运动神经元疾病，尽管人们已经认识到运动外变性，特别是在表现为ALS的额颞痴呆（ALS-FTD）的额颞区。先前对ALS‐FTD患者的大脑进行的神经影像学研究已经测量到灰质（GM）或白质（WM）结构的异常，但未发现两者的异常。因此，目的是使用功能性和结构性神经影像学评估同一位ALS-FTD患者的GM和WM。通过这样做，可以了解ALS-FTD中的神经变性主要是神经病还是轴突病。