The mature naïve B cell repertoire consists of three well-defined populations: B1, B2 (follicular B, FOB), and marginal zone B (MZB) cells. FOB cells are the dominant mature B cell population in the secondary lymphoid organs and blood of both humans and mice. The driving forces behind mature B lineage selection have been linked to B cell receptor (BCR) signaling strength and environmental cues, but how these fate-determination factors are transcriptionally regulated remains poorly understood. We summarize emerging data on the role of transcription factors (TFs) – particularly the ETS and IRF families – in regulating MZB and FOB lineage selection. Indeed, genomic analyses have identified four major groups of target genes that are crucial for FOB differentiation, revealing previously unrecognized pathways that ultimately determine biological responses specific to this lineage.

成熟的原始B细胞库由三个定义明确的种群组成：B1，B2（卵泡B，FOB）和边缘区B（MZB）细胞。FOB细胞是人类和小鼠次要淋巴器官和血液中主要的成熟B细胞群体。成熟的B谱系选择背后的驱动力已与B细胞受体（BCR）信号强度和环境提示相关联，但如何命运决定这些命运决定因素的转录调控仍知之甚少。我们总结了有关转录因子（TF），特别是ETS和IRF家族，在调节MZB和FOB谱系选择中的作用的新兴数据。实际上，基因组分析已经确定了四大类目标基因，它们对FOB的分化至关重要，