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The impact of manganese on neurotransmitter systems.
Journal of Trace Elements in Medicine and Biology ( IF 3.5 ) Pub Date : 2020-05-20 , DOI: 10.1016/j.jtemb.2020.126554
Ana Thalita Gonçalves Soares 1 , Aline de Castro Silva 1 , Alexey A Tinkov 2 , Haroon Khan 3 , Abel Santamaría 4 , Margarita G Skalnaya 5 , Anatoly V Skalny 6 , Aristidis Tsatsakis 7 , Aaron B Bowman 8 , Michael Aschner 9 , Daiana Silva Ávila 1
Affiliation  

Background

Manganese (Mn) is a metal ubiquitously present in nature and essential for many living organisms. As a trace element, it is required in small amounts for the proper functioning of several important enzymes, and reports of Mn deficiency are indeed rare.

Methods

This mini-review will cover aspects of Mn toxicokinetics and its impact on brain neurotransmission, as well as its Janus-faced effects on humans and other animal’s health.

Results

The estimated safe upper limit of intracellular Mn for physiological function is in anarrow range of 20–53 μM.Therefore, intake of higher levels of Mn and the outcomes, especially to the nervous system, have been well documented.

Conclusion

The metal affects mostly the brain by accumulating in specific areas, altering cognitive functions and locomotion, thus severely impacting the health of the exposed organisms.



中文翻译:

锰对神经递质系统的影响。

背景

锰 (Mn) 是一种普遍存在于自然界中的金属,是许多生物体所必需的。作为一种微量元素,它是几种重要酶正常运作所必需的少量元素,关于锰缺乏症的报道确实很少见。

方法

这篇小型综述将涵盖锰毒代动力学的各个方面及其对大脑神经传递的影响,以及它对人类和其他动物健康的两面性影响。

结果

细胞内锰对生理功能的估计安全上限在 20-53 μM 的狭窄范围内。因此,摄入更高水平的锰和结果,尤其是对神经系统的影响,已得到充分证明。

结论

金属主要通过在特定区域积累、改变认知功能和运动来影响大脑,从而严重影响暴露生物的健康。

更新日期:2020-05-20
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