Background

Several studies have investigated the association between selenium levels and skin diseases, but reached inconsistent results.

Objective

This systematic review and meta-analysis was conducted to evaluate the association between selenium levels and skin diseases.

Methods

A systematic search was conducted in public databases to identify all relevant studies, and study-specific standard mean differences (SMD) and 95% confidence intervals (CI) were pooled to compare the selenium levels between different groups.

Results

Twenty-seven studies were identified with a total of 1315 patient and 7181 healthy controls. Compared with controls, no significant difference in selenium was found in patients with vitiligo (SMD = 0.53, 95% CI: –0.40 to 1.45), alopecia areata (SMD = 0.47, 95% CI: –2.72 and 3.65), or eczema (SMD = 0.12, 95% CI: –0.24 to 0.48). A lower selenium level was found in patients with psoriasis (SMD = –0.62, 95% CI: –1.15 to –0.10), acne vulgaris (SMD = –1.02, 95% CI: –1.45 to –0.60), chloric acne (SMD = –2.35, 95% CI: –3.15 to –1.55), and atopic dermatitis (SMD = –2.62, 95% CI: –3.00 to –2.24). As for disease severity, severe patients had a higher selenium level than mild patients in psoriasis (SMD = 0.72, 95% CI: 0.07–1.38), but no difference was found in vitiligo (SMD = –0.26, 95% CI: –2.38 to 1.85) and alopecia areata (SMD = 0.46, 95% CI: –0.34 to 1.26).

Conclusion

Selenium levels were associated with several skin diseases and the disease severity, and high selenium levels tended to be a protective factor in certain skin diseases.

中文翻译：

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硒水平和皮肤病：系统评价和荟萃分析。

背景

几项研究调查了硒水平与皮肤病之间的关联，但得出的结果不一致。

目标

进行这项系统评价和荟萃分析是为了评估硒水平与皮肤病之间的关联。

方法

在公共数据库中进行系统搜索以识别所有相关研究，并汇总研究特定标准平均差 (SMD) 和 95% 置信区间 (CI) 以比较不同组之间的硒水平。

结果

共有 1315 名患者和 7181 名健康对照者共确定了 27 项研究。与对照组相比，在白癜风（SMD = 0.53，95% CI：–0.40 至 1.45）、斑秃（SMD = 0.47，95% CI：–2.72 和 3.65）或湿疹（ SMD = 0.12，95% CI：–0.24 到 0.48）。在银屑病（SMD = –0.62，95% CI：–1.15 至 –0.10）、寻常痤疮（SMD = –1.02，95% CI：–1.45 至 –0.60）、氯性痤疮（SMD）患者中发现硒水平较低= –2.35，95% CI：–3.15 至 –1.55）和特应性皮炎（SMD = –2.62，95% CI：–3.00 至 –2.24）。至于疾病严重程度，银屑病重症患者的硒水平高于轻度患者（SMD = 0.72, 95% CI: 0.07–1.38），但白癜风无差异（SMD = –0.26, 95% CI: –2.38）至 1.85）和斑秃（SMD = 0.46，95% CI：–0.34 至 1。

结论

硒水平与多种皮肤病和疾病严重程度有关，高硒水平往往是某些皮肤病的保护因素。