BACKGROUND Specific cognitive rehabilitation (SCR) has been suggested for multiple sclerosis (MS). A randomized controlled trial (RCT) evaluating the therapeutic effects of SCR is necessary. OBJECTIVE To demonstrate the superiority of a SCR program (REACTIV) over nonspecific intervention (NSI) for neuropsychological (NP) assessment, virtual reality (VR) cognitive testing and daily cognitive functioning. METHODS A single-blind RCT compared SCR and NSI in patients with MS with cognitive complaint. Both programs included 50 individual sessions, 3 times a week for 17 weeks in a real-world setting. The primary end-point was NP assessment. Secondary end-points included semiecological VR tasks (Urban Daily Cog®) and daily cognitive functioning assessment. Maintenance of the effects at 8 months was studied. RESULTS Of the 35 patients, 18 completed the SCR, and 17 completed the NSI. Several NP and semiecological scores improved significantly more after SCR than after NSI. More NP scores improved significantly after SCR than after NSI. SCR improved daily cognitive functioning. Most improvements were maintained at 8 months. CONCLUSION SCR performed in a real-world setting is superior to NSI for improving performance in specific cognitive domains and information processing speed, and for improving cognitive functioning, as evaluated by ecological tools close to daily life and a daily cognitive functioning questionnaire.

中文翻译：

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认知康复对神经心理学和半生态学测试以及多发性硬化症日常认知功能的影响：REACTIV 随机对照研究

背景技术已经建议针对多发性硬化症（MS）进行特定的认知康复（SCR）。一项评估 SCR 治疗效果的随机对照试验 (RCT) 是必要的。目的 证明 SCR 程序 (REACTIV) 在神经心理学 (NP) 评估、虚拟现实 (VR) 认知测试和日常认知功能方面优于非特异性干预 (NSI)。方法 一项单盲 RCT 比较了患有认知障碍的 MS 患者的 SCR 和 NSI。这两个项目都包括 50 个单独的课程，每周 3 次，为期 17 周，在真实环境中进行。主要终点是NP评估。次要终点包括半生态 VR 任务（Urban Daily Cog®）和日常认知功能评估。研究了 8 个月时效果的维持情况。结果 在 35 名患者中，18 名完成了 SCR，17 人完成了 NSI。一些 NP 和半生态学评分在 SCR 后比在 NSI 后显着提高。与 NSI 相比，SCR 后更多的 NP 分数显着提高。SCR 改善了日常认知功能。大多数改进保持在 8 个月。结论 在现实世界环境中进行的 SCR 在提高特定认知领域的表现和信息处理速度以及改善认知功能方面优于 NSI，正如通过接近日常生活的生态工具和日常认知功能问卷评估的那样。