BACKGROUND The cerebellum is known to play a crucial role in sensori-motor adaptation, which includes the prism adaptation. TRH has been widely used as a treatment for cerebellar ataxia in Japan, however effects of TRH on cerebellar adaptation process have not been studied. Here, we studied effects of TRH treatment on the prism adaptation task. METHODS Eighteen spinocerebellar degeneration (SCD) patients participated in this study. The participants received intravenous injection of 2 mg/day protirelin tartrate once a day for 14 days. In the prism adaptation task, the participants reached to the target on the screen wearing wedge prisms. We compared the Scale for Assessment and Rating of Ataxia (SARA), baseline errors and the aftereffect (AE) of the prism adaptation task between before and after TRH therapy. RESULTS TRH therapy improved SARA significantly (p = .005). Multiple regression analysis revealed that improvement of SARA score was mainly due to improvement of "Stance" category score. TRH decreased baseline errors of the prism adaptation task (p = .021), while unaffected AEs (p = .252). CONCLUSION TRH differentially affected clinical cerebellar ataxia including baseline reaching performance in the prism adaptation task, whereas TRH did not affect the learning process of prism adaptation. Different cerebellar functional aspects may underlie the learning process of sensori-motor adaptation and simple motor execution (clinically evaluated cerebellar ataxia).

中文翻译：

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促甲状腺激素释放激素（TRH）对脊髓小脑变性患者运动执行和运动适应过程的影响

背景已知小脑在感觉运动适应中起关键作用，其中包括棱镜适应。TRH在日本已广泛用于治疗小脑共济失调，但尚未研究TRH对小脑适应过程的影响。在这里，我们研究了 TRH 处理对棱镜适应任务的影响。方法 18 名脊髓小脑变性 (SCD) 患者参加了这项研究。参与者每天接受一次 2 毫克/天的酒石酸 protirelin 静脉注射，持续 14 天。在棱镜适应任务中，参与者佩戴楔形棱镜到达屏幕上的目标。我们比较了 TRH 治疗前后的共济失调评估量表 (SARA)、基线误差和棱镜适应任务的后遗症 (AE)。结果 TRH 治疗显着改善了 SARA (p = .005)。多元回归分析显示，SARA评分的提高主要是由于“Stance”类别评分的提高。TRH 降低了棱镜适应任务的基线误差 (p = .021)，而未受影响的 AE (p = .252)。结论 TRH 对临床小脑共济失调的影响不同，包括棱镜适应任务中的基线达到性能，而 TRH 不影响棱镜适应的学习过程。不同的小脑功能方面可能是感觉运动适应和简单运动执行（临床评估的小脑共济失调）的学习过程的基础。TRH 降低了棱镜适应任务的基线误差 (p = .021)，而未受影响的 AE (p = .252)。结论 TRH 对临床小脑共济失调的影响不同，包括棱镜适应任务中的基线达到性能，而 TRH 不影响棱镜适应的学习过程。不同的小脑功能方面可能是感觉运动适应和简单运动执行（临床评估的小脑共济失调）的学习过程的基础。TRH 降低了棱镜适应任务的基线误差 (p = .021)，而未受影响的 AE (p = .252)。结论 TRH 对临床小脑共济失调的影响不同，包括棱镜适应任务中的基线达到性能，而 TRH 不影响棱镜适应的学习过程。不同的小脑功能方面可能是感觉运动适应和简单运动执行（临床评估的小脑共济失调）的学习过程的基础。