Cytosolic DNA detection via the DNA sensor cGAS initiates a major cell-intrinsic response to infection and malignancies. In this issue of Immunity, Zhou et al. (2020) report that the catalytic product of cGAS, cGAMP, can alert bystander cells over large distances through its cell-to-cell transmission via volume-regulated anion channels.

中文翻译：

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来自遥远邻居的警报：通过阴离子通道传播抗病毒免疫力。

通过DNA传感器cGAS进行的胞质DNA检测可引发对感染和恶性肿瘤的主要细胞内在反应。在本期《免疫》中，Zhou等人。（2020）报告说，cGAS的催化产物cGAMP可以通过其通过体积调节的阴离子通道进行的细胞间传输，在很长的距离内警告旁观者细胞。