The coronavirus disease 2019 (COVID-19) pandemic caused by SARS-CoV-2 has had devastating global impacts and will continue to have dramatic effects on public health for years to come. A better understanding of the immune response to SARS-CoV-2 will be critical for the application and development of therapeutics. The degree to which the innate immune response confers protection or induces pathogenesis through a dysregulated immune response remains unclear. In this review, we discuss what is known about the role of the innate immune system during SARS-CoV-2 infection, suggest directions for future studies, and evaluate proposed COVID-19 immunomodulating therapeutics.

由SARS-CoV-2引起的2019年冠状病毒疾病（COVID-19）大流行已经给全球造成了毁灭性影响，并将在未来几年继续对公共卫生产生巨大影响。更好地了解SARS-CoV-2的免疫反应对于治疗剂的应用和开发至关重要。尚不清楚先天免疫应答通过失调的免疫应答赋予保护或诱导发病机理的程度。在这篇综述中，我们讨论了有关先天免疫系统在SARS-CoV-2感染过程中的作用的已知信息，为今后的研究提供了方向，并评估了拟议的COVID-19免疫调节疗法。