Healing of diabetic wounds are delayed due to late initiation and prolongation of the inflammatory phase, and inadequate growth factor synthesis, which may lead to chronic ulcers that may cause limb amputation, besides making the patients vulnerable to infections. In recent years, it has been extensively discussed whether different cell types transplanted to diabetic wound models accelerate wound healing.

In this study, the effect of dermis-derived cells on Streptozotocin (STZ) induced experimental diabetic Sprague-Dawley rats were investigated. Animals were divided into 3 groups. First group was control, second group included diabetic animals with wounds. In the third group, firstly, skin specimens were obtained from animal’s back, and then primary explant culture was performed. STZ induced experimental diabetes was applied to these animals and then wound was opened. The cells grown in primary culture were transplanted autologously. In all three groups, the samples taken from the wound areas on the 5th and 15th days of the wound were examined at the level of histochemical and immunohistochemical and electron microscopy.

In the study, it was observed that the decreasing α-SMA and KGF (FGF-7) expression in the early period especially in the case of experimental diabetes increased as a result of cell transplantation, and in the sections belonging to the experimental diabetic group, a large number of inflammatory cells in the wound area were removed from the environment. In the cell transplanted group, the collagen fiber bundles as if in the control group.

As a result, healthy cells of dermis can act as mesenchymal stem cells under certain conditions and have a positive effect on diabetic wound healing.

糖尿病伤口的愈合由于炎性阶段的延迟开始和延长以及生长因子合成不足而延迟，这不仅可能导致慢性溃疡，还可能导致肢体截肢，这不仅使患者容易感染。近年来，已经广泛讨论了移植到糖尿病伤口模型中的不同细胞类型是否能促进伤口愈合。

在这项研究中，研究了真皮来源的细胞对链脲佐菌素（STZ）诱导的实验性糖尿病Sprague-Dawley大鼠的影响。将动物分为3组。第一组是对照组，第二组包括有伤口的糖尿病动物。在第三组中，首先从动物的背部获得皮肤样本，然后进行原代外植体培养。将STZ诱导的实验性糖尿病应用于这些动物，然后打开伤口。在原代培养中生长的细胞自体移植。在所有三组中，均在组织化学和免疫组织化学以及电子显微镜下检查在伤口第5天和第15天从伤口区域采集的样品。

在该研究中，观察到早期α-SMA和KGF（FGF-7）表达的降低，特别是在实验性糖尿病的情况下，由于细胞移植而增加，并且在属于实验性糖尿病组的部分中，伤口区域的大量炎性细胞已从环境中清除。在细胞移植组中，胶原纤维像对照组一样捆扎。

结果，健康的真皮细胞可以在一定条件下充当间充质干细胞，对糖尿病伤口的愈合具有积极作用。