While the epidemic of Coronavirus disease 2019 (COVID-19) continues to spread globally, more and more evidences are collected about the presence of neurological manifestations and symptoms associated with it. A systematic review has been performed of papers published until 5 April 2020. 29 papers related to neurological manifestations associated with COVID-19 were examined. The results show presence of central and peripheral nervous system manifestations related to coronavirus. Neurological manifestations, or NeuroCOVID, are part of the COVID-19 clinical picture, but questions remain regarding the frequency and severity of CNS symptoms, the mechanism of action underlying neurological symptoms, and the relationship of symptoms with the course and severity of COVID-19. Further clinical, epidemiological, and basic science research is urgently needed to understand and address neurological sequalae of COVID-19. Concomitant risk factors or determinants (e.g. demographic factors, comorbidities, or available biomarkers) that may predispose a person with COVID-19 to neurological manifestations also need to be identified. The review shows that although more and more papers are reporting neurological manifestations associated with COVID-19; however, many items remain unclear and this uncertainty calls for a global action that requires close coordination and open-data sharing between hospitals, academic institutions and the fast establishment of harmonised research priorities and research consortia to face the NeuroCOVID-19 complications.

中文翻译：

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与 COVID-19 相关的神经系统表现：回顾和行动呼吁。

虽然 2019 年冠状病毒病 (COVID-19) 的流行继续在全球蔓延，但越来越多的证据表明存在神经系统表现和与之相关的症状。对截至 2020 年 4 月 5 日发表的论文进行了系统审查。审查了 29 篇与 COVID-19 相关的神经系统表现相关的论文。结果显示存在与冠状病毒相关的中枢和外周神经系统表现。神经系统表现或 NeuroCOVID 是 COVID-19 临床表现的一部分，但关于 CNS 症状的频率和严重程度、神经系统症状的作用机制以及症状与 COVID-19 病程和严重程度的关系仍然存在问题. 进一步的临床、流行病学、迫切需要基础科学研究来了解和解决 COVID-19 的神经系统后遗症。还需要确定可能使 COVID-19 患者易患神经系统表现的伴随风险因素或决定因素（例如人口统计学因素、合并症或可用的生物标志物）。审查表明，尽管越来越多的论文报告了与 COVID-19 相关的神经系统表现；然而，许多项目仍不清楚，这种不确定性要求采取全球行动，需要医院、学术机构之间密切协调和开放数据共享，并快速建立协调一致的研究重点和研究联盟，以应对 NeuroCOVID-19 并发症。还需要确定可能使 COVID-19 患者易患神经系统表现的人口统计学因素、合并症或可用的生物标志物。审查表明，尽管越来越多的论文报告了与 COVID-19 相关的神经系统表现；然而，许多项目仍不清楚，这种不确定性要求采取全球行动，需要医院、学术机构之间密切协调和开放数据共享，并快速建立协调一致的研究重点和研究联盟，以应对 NeuroCOVID-19 并发症。还需要确定可能使 COVID-19 患者易患神经系统表现的人口统计学因素、合并症或可用的生物标志物。审查表明，尽管越来越多的论文报告了与 COVID-19 相关的神经系统表现；然而，许多项目仍不清楚，这种不确定性要求采取全球行动，需要医院、学术机构之间密切协调和开放数据共享，并快速建立协调一致的研究重点和研究联盟，以应对 NeuroCOVID-19 并发症。