Inflammation is a universal response mechanism existing as inter-communicator of biological systems. Uncontrolled or dysregulated inflammation addresses chronic low-grade effects eventually resulting in multimorbidity. Active solute transport across the membrane establishes varying osmotic gradients. Aquaporins (AQPs) are a class of critical ubiquitously expressed transmembrane proteins that aid in fluid and small solute transport via facilitated diffusion over established osmotic gradients. Numerous significant data features the biological functions of AQPs rendering them as an appropriate biomarker of health and diseases. Besides their physiological role in well-balanced inflammatory responses, it is worth noting the dysregulation of AQPs during any undesirable inflammatory event. Most literature to date clearly sets out AQPs as potential drug targets instigating AQP-based therapies. In light of this conception, the current review provides a compendious overview on the propitious and portentous out-turns of AQPs under inflammation.

中文翻译：

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水通道蛋白在炎症中的作用-科学的治疗方法。

炎症是作为生物系统的相互传播者而存在的普遍反应机制。不受控制或失调的炎症可解决慢性低度效应，最终导致多发病。跨膜的有效溶质运输建立了不同的渗透梯度。水通道蛋白（AQPs）是一类关键的普遍表达的跨膜蛋白，可通过在已确定的渗透梯度上促进扩散来帮助流体和少量溶质运输。大量重要数据具有AQPs的生物学功能，使其成为健康和疾病的适当生物标记。除了它们在平衡炎症反应中的生理作用外，值得注意的是在任何不良炎症事件中AQP的失调。迄今为止，大多数文献都清楚地将AQP列为激发基于AQP疗法的潜在药物靶标。根据这一概念，本篇综述提供了有关炎症条件下AQP的有利和不利转折的简要概述。