An on-chip device has been fabricated on Si platform for precise estimation of the hematocrit (Hct) level of human blood with rapid turn out. Impedance/capacitance spectroscopy and current-voltage (I-V) measurements have been employed to observe the variation of electrical parameters of erythrocyte suspensions with varying Hct level. Experimentally obtained values of capacitance, impedance and conductance with Hct level suggests a linear variation. Current-time measurement has also been performed to ensure the susceptibility of red blood cells under a fixed external electric field for certain duration of time. The online real time sample analyzes have also been performed by the device connected with an embedded electronic circuit interfaced with a laptop through appropriate software. This has enabled the development of a novel Si-chip based compact point-of-care (POC) diagnosis system for Hct level estimation by measuring the dielectric/capacitive variation of an erythrocyte cell suspension. The relevant performance parameters of such a compact system including range, resolution, limit of detection and throughput have also been evaluated.

中文翻译：

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片上血细胞比容水平的估计，用于通过阻抗技术诊断贫血。

已经在Si平台上制造了一种片上设备，用于快速估算出人类血液的血细胞比容（Hct）水平。阻抗/电容光谱法和电流-电压（IV）测量已被用来观察具有不同Hct水平的红细胞悬液的电参数的变化。通过实验获得的电容，阻抗和电导的Hct值表明存在线性变化。还进行了电流时间测量，以确保在固定的外部电场下一定时间段内对红细胞的敏感性。在线实时样本分析也已经通过与通过适当软件与笔记本电脑接口的嵌入式电子电路连接的设备进行了。这使得能够开发新的基于Si芯片的紧凑型即时诊断（POC）诊断系统，用于通过测量红细胞悬浮液的介电/电容变化来估算Hct水平。还已经评估了这种紧凑系统的相关性能参数，包括范围，分辨率，检测极限和通量。