当前位置: X-MOL 学术Arch. Toxicol. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
Biotransformation of arsenic and toxicological implication of arsenic metabolites.
Archives of Toxicology ( IF 6.1 ) Pub Date : 2020-05-20 , DOI: 10.1007/s00204-020-02772-9
Seishiro Hirano 1
Affiliation  

Arsenic is a well-known environmental carcinogen and chronic exposure to arsenic through drinking water has been reported to cause skin, bladder and lung cancers, with arsenic metabolites being implicated in the pathogenesis. In contrast, arsenic trioxide (As2O3) is an effective therapeutic agent for the treatment of acute promyelocytic leukemia, in which the binding of arsenite (iAsIII) to promyelocytic leukemia (PML) protein is the proposed initial step. These findings on the two-edged sword characteristics of arsenic suggest that after entry into cells, arsenic reaches the nucleus and triggers various nuclear events. Arsenic is reduced, conjugated with glutathione, and methylated in the cytosol. These biotransformations, including the production of reactive metabolic intermediates, appear to determine the intracellular dynamics, target organs, and biological functions of arsenic.

中文翻译:

砷的生物转化和砷代谢产物的毒理学意义。

砷是一种众所周知的环境致癌物,据报道,通过饮用水长期接触砷会引起皮肤癌,膀胱癌和肺癌,其中砷代谢物与发病机理有关。相反,三氧化二砷(As2O3)是治疗急性早幼粒细胞白血病的有效治疗剂,其中砷(iAsIII)与早幼粒细胞白血病(PML)蛋白的结合是拟议的初始步骤。这些关于砷的两刃剑特性的发现表明,砷进入细胞后,到达核并触发各种核事件。砷被还原,与谷胱甘肽结合,并在细胞质中甲基化。这些生物转化,包括反应性代谢中间体的产生,似乎决定了细胞内动力学,靶器官,
更新日期:2020-05-20
down
wechat
bug