Owing to the inherent ability of amides to chelate transition-metal catalysts, amide-directed C–H activation reactions constitute a major tactic in directed C–H activation reactions. While the conventional procedures for these reactions usually involve prior preparation and purification of amide substrates before the C–H activation, the step economy is actually undermined by the operation of installing the directing group (DG) and related substrate purification. In this context, directed C–H activation via in situ amidation of the crude material provides a new protocol that can significantly enhance the step economy of amide-directed C–H activation. In this short review, the advances in C–H bond activation reactions mediated or initiated by in situ amidation are summarized and analyzed.

中文翻译：

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原位酰胺化指导的一步经济的C–H活化反应

由于酰胺具有螯合过渡金属催化剂的固有能力，酰胺导向的CH活化反应是定向CH活化反应的主要策略。尽管这些反应的常规程序通常涉及在C–H活化之前事先准备和纯化酰胺底物，但实际上通过安装导向基团（DG）和相关的底物纯化操作会损害步伐经济性。在这种情况下，通过原油的原位酰胺化进行的定向C–H活化提供了新的方案，可以显着提高酰胺导向的C–H活化的步骤经济性。在这篇简短的综述中，总结和分析了由原位酰胺化介导或引发的CH键活化反应的进展。