Ideally, alloplastic dural substitute should have functional properties resembling human dura mater and retain a watertight closure to prevent cerebrospinal leakage. Therefore, functional properties for successful dural closure application of newly developed bilayer oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites were studied and compared with human cadaveric dura mater and three commercial dural substitutes including two collagen matrices and one synthetic poly-L-lactide patch. It was found that oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites uniquely contained a bilayer structure consisting of micropores distributed within the relatively dense microstructure. Density, tensile properties and stitch tear strength of oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites were found to be closed to human cadaveric dura mater than those of dense-type and porous-type dural substitutes. Water tightness performance in both sutured and non-sutured forms of oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composites was slightly inferior to human cadaveric dura mater, but still better than those of commercial dural substitutes. This study revealed that oxidized regenerated cellulose knitted fabric/poly ε-caprolactone knitted fabric-reinforced composite showed better functional properties than typical dural substitutes and was found to be a good candidate for being employed as a dural substitute. The role and relationship of both microstructure and the type of materials on the functional properties and water tightness of the dural substitutes were also elucidated.

中文翻译：

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双层氧化再生纤维素/聚ε-己内酯针织物增强硬脑膜替代品的性能评估。

理想情况下，同种异体硬脑膜替代物应具有类似于人硬脑膜的功能特性，并保持水密性封闭，以防止脑脊液漏出。因此，研究了成功开发新型双层氧化再生纤维素针织物/聚ε-己内酯针织物增强复合材料的硬脑膜的功能特性，并将其与人尸体硬脑膜和三种商业硬脑膜替代品进行了比较，其中包括两种胶原蛋白基质和一种合成聚丙烯酸酯-L-丙交酯贴剂。发现氧化的再生纤维素针织物/聚ε-己内酯针织物增强的复合材料独特地包含由分布在相对致密的微结构内的微孔组成的双层结构。密度，发现氧化再生纤维素针织物/聚ε-己内酯针织物增强的复合材料的拉伸性能和缝线撕裂强度比致密型和多孔型硬脑膜替代物更接近人体尸体硬脑膜。缝合形式和非缝合形式的氧化再生纤维素针织物/聚ε-己内酯针织物增强的复合材料的水密性均略逊于人体尸体硬脑膜，但仍优于商用硬脑膜替代物。这项研究表明，氧化再生纤维素针织物/聚ε-己内酯针织物增强的复合材料比典型的硬脑膜替代品具有更好的功能性能，并且被发现可以用作硬脑膜替代品。