Detailed process safety investigation of an old process revealed hidden, previously unnoticed danger. The synthesis of morpholine-adduct 2 was performed under reaction conditions very close to triggering a potentially dangerous runaway reaction. Process modifications such as dilution with an inert solvent allowed gaining better control of the process. Ultimately, improvement in both quality and yield was obtained.

中文翻译：

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不断提高安全性，避免失控反应：氯噻二唑中间体合成对替莫洛的情况

对旧过程进行的详细过程安全调查显示出隐藏的，以前未注意到的危险。吗啉加合物2的合成在非常接近引发潜在危险的失控反应的反应条件下进行。改进工艺，例如用惰性溶剂稀释，可以更好地控制工艺。最终，质量和产量都得到了提高。