Abstract

An eco-compatible, facile and clean strategy for the synthesis of 1, 4-dihydropyridine (1, 4-DHP) derivatives has been reported through one pot multi-component Hantzsch reaction using glycerol as a promoting medium. A nontoxic and cheap by-product of biodiesel industry i.e., glycerol has been utilized as a reaction condition in our protocol. The reported protocol offers a greener, economical and expeditious synthesis of biologically significant 1, 4-DHPs with moderate to excellent yields with high atom economy under metal free mild reaction conditions. In addition, operational simplicity, cost effectiveness, and reusability are the additional advantages of our protocol with the avoidance of hazardous volatile solvents.

摘要

通过使用甘油作为促进介质的一锅多组分 Hantzsch 反应，报道了一种生态相容、简便且清洁的 1, 4-二氢吡啶 (1, 4-DHP) 衍生物合成策略。在我们的协议中，生物柴油工业的一种无毒且廉价的副产品，即甘油已被用作反应条件。报告的协议提供了一种更绿色、经济和快速的生物重要 1, 4-DHP 合成，在无金属温和反应条件下具有中等至优异的产率和高原子经济性。此外，操作简单、成本效益和可重复使用性是我们协议的额外优势，避免了危险的挥发性溶剂。