Longevity of plasma cells is dependent on their ability to access and reside in so‐called survival niches that are predominantly located in the bone marrow. It is proposed that by some process a small fraction of the plasma cells generated in response to new antigen challenges can enter into the long‐lived repertoire by displacing existing plasma cells. Several lines of research show that this process is not stochastic as not all resident, long‐lived plasma cells appear equally likely to be displaced. The basis of these differences might reside in the niches, the plasma cells or a combination of both factors that intersect to create a distribution of susceptibility to replacement and lifespans. In this review, I consider factors that might vary in plasma cells and thus influence their access to niches and the ability of newly generated plasma cells to survive over the long term.

中文翻译：

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浆细胞是否有助于确定其寿命？

浆细胞的寿命取决于它们进入和驻留在主要位于骨髓中的所谓生存壁ni中的能力。建议通过某些过程通过置换现有浆细胞进入新的抗原挑战而产生的一小部分浆细胞进入长期存在的库。几项研究表明，此过程并非随机的，因为并非所有驻留的长寿命浆细胞都似乎同样有可能被置换。这些差异的基础可能在于壁the，浆细胞或相交形成对替换和寿命的敏感性分布的两个因素的组合。在这篇评论中