Simultaneous characterization and quantification of flavonoids in Morus australis root as potential hepatoprotective nutraceutical.,Journal of Food Biochemistry

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Simultaneous characterization and quantification of flavonoids in Morus australis root as potential hepatoprotective nutraceutical.
Journal of Food Biochemistry ( IF 4 ) Pub Date : 2020-05-19 , DOI: 10.1111/jfbc.13259
Sen Guo _{1,

2} , Xiameng Ren ₂ , Junfeng Du ₃ , Shanshan Zhang _{1,

2} , Tianyi Wang ₂ , Hai Zhang ₄ , Haoan Zhao ₂ , Wenping Yue ₁ , Chi-Tang Ho ₅ , Naisheng Bai ₂

Affiliation

Morus australis distributed widely in China has high value in food and agriculture. Twelve phenolic compounds were isolated and identified as major constituents of M. australis root from Shaanxi province, China, while the protective effect of M. australis root on liver injury has never been determined in detail. In this study, the hepatoprotective ability of M. australis root was investigated in vivo and in vitro. The ethanol‐water extract prepared from M. australis root showed protection on alcohol‐induced liver damage in mice by decreasing the levels of serum alanine aminotransferase, aspartate transaminase, triacylglycerol and malondialdehyde, and by increasing glutathione contents. Furthermore, among 12 major constituents of M. australis root, 10 flavonoids (especially 1) showed protection against carbon tetrachloride (CCl₄)‐intoxicated HepG2 cell lines by decreased lactic dehydrogenase levels. In addition a validated HPLC‐DAD method was established for the quantitative analysis of 10 flavonoids in the bioactive extract.

更新日期：2020-05-19

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