Attaching functional nanomaterials onto tile‐based DNA nanocages to form hybrids consisting of DNA nanocages and nanomaterial clusters with well‐defined compositions might not only integrate the functions of each component, but also potentially lead to new emergent properties and applications. Herein, we report a general and facile hybridization‐driven approach for functionalizing tile‐based nanocages with gold nanoparticles (AuNPs) to form AuNP cluster‐DNA cage hybrids. AuNP tetramer‐DNA tetrahedron hybrids and AuNP octamer‐DNA octahedron complexes have been successfully fabricated. Our hybridization‐based strategy could in principle be extended to fabricate various hybrids with designable compositions and structures due to the diversity of tile‐based nanocages and the great variety of functional nanomaterials that could be modified with DNA, which should hold the promise of greatly promoting the research of bio/nanoassembly.

中文翻译：

---

基于金纳米颗粒（AuNP）的基于Tile的DNA纳米笼的功能化，以形成AuNP簇DNA笼杂交体

将功能性纳米材料附着在基于图块的DNA纳米笼上，形成由DNA纳米笼和具有明确定义组成的纳米材料簇组成的杂化物，不仅可以整合每个组件的功能，而且还可能带来新的新兴特性和应用。本文中，我们报道了一种通用且简便的杂交驱动方法，用于将带有金纳米颗粒（AuNPs）的基于瓦的纳米笼功能化，以形成AuNP簇-DNA笼杂种。AuNP四聚体-DNA四面体杂物和AuNP八聚体-DNA八面体复合物已成功制备。由于基于瓦的纳米笼子的多样性和可以用DNA修饰的功能纳米材料的多样性，我们的基于杂交的策略原则上可以扩展到制造具有可设计的组成和结构的各种杂种。