Molecular networking approach was applied for the targeted isolation of new sterigmatocystin derivatives, sterigmatocystins A–C, from the marine sponge‐derived fungus Aspergillus versicolor. Sterigmatocystin A features a rare 6/6/6/6/5 polycyclic system. The structures of sterigmatocystins A–C, including absolute configurations, were determined on the basis of spectroscopic data and ECD calculations. Sterigmatocystin A showed more stronger promoting angiogenesis activity than the positive control at 1.25 μM level in transgenic fluorescent zebrafish. Sterigmatocystins A–C also exhibited moderate antiviral activity by the inhibition of HSV‐2.

中文翻译：

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分子网络方法指导下的真菌杂色曲霉中三种新的杂色曲霉衍生物的分离与鉴定-【维普网】-仓储式在线作品出版平台-www.cqvip.com

分子网络方法用于从海绵来源的真菌花曲霉中靶向分离新的 sterigmatocystin 衍生物，即 sterigmatocystins A-C。Sterigmatocystin A 具有罕见的 6/6/6/6/5 多环系统。sterigmatocystins A-C 的结构，包括绝对构型，是根据光谱数据和 ECD 计算确定的。Sterigmatocystin A 在转基因荧光斑马鱼中显示出比 1.25 μM 水平的阳性对照更强的促进血管生成活性。Sterigmatocystins A-C 还通过抑制 HSV-2 表现出中等的抗病毒活性。