Nonalcoholic fatty liver disease (NAFLD) significantly impacts global health. Despite considerable research, its pathophysiology remains partially unclear. In addition, selective serum biomarkers of disease diagnosis and progression are missing. Long noncoding RNAs (lncRNAs) are a heterogeneous group of ncRNAs with crucial roles in biological processes underlying the pathophysiology of different human diseases. Recent studies have shown that lncRNA could be associated with the genesis and progression of NAFLD towards the most severe forms. Although the field is still in its infancy, it is tempting to speculate that these transcripts could be used as both diagnostic and therapeutic targets. In this review, we summarize recent findings on lncRNAs in the complex research field of NAFLD.

非酒精性脂肪肝 (NAFLD) 显着影响全球健康。尽管进行了大量研究，但其病理生理学仍部分不清楚。此外，缺少疾病诊断和进展的选择性血清生物标志物。长链非编码 RNA (lncRNA) 是一组异质性的 ncRNA，在不同人类疾病病理生理学的生物学过程中起着至关重要的作用。最近的研究表明，lncRNA 可能与 NAFLD 向最严重形式的发生和进展有关。尽管该领域仍处于起步阶段，但人们很容易推测这些转录本可用作诊断和治疗目标。在这篇综述中，我们总结了 NAFLD 复杂研究领域中 lncRNA 的最新发现。