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Discovery of the Endophytic Fungi from Polygonum cuspidatum and Biotransformation of Resveratrol to Pterostillbene by the Endophyte Penicillium sp. F5
Applied Biochemistry and Microbiology ( IF 0.8 ) Pub Date : 2020-05-19 , DOI: 10.1134/s0003683820030163 Z. Xu , J. Tian , L. Gan , Y. Tian
中文翻译:
从虎杖中发现内生真菌,并通过内生青霉菌将白藜芦醇生物转化为紫草烯。F5
更新日期:2020-05-19
Applied Biochemistry and Microbiology ( IF 0.8 ) Pub Date : 2020-05-19 , DOI: 10.1134/s0003683820030163 Z. Xu , J. Tian , L. Gan , Y. Tian
Abstract
In this study, fungal endophytes were screened from samples of Polygonum cuspidatum and 24 endophytes were obtained. The fungal endophytes were allocated to 6 orders and 9 genera by phylogenetic analysis. Based on the ability of fungal endophytes to induce biotransformation, Penicillium sp. F5 was selected for the biotransformation of resveratrol. Fermentation of media using Penicillium sp. F5 yielded transformation products, giving a main product that was purified using silica gel column chromatography. The structure of main product was established as pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene) by using 1H-NMR, 13C -NMR, HSQC and HMBC spectroscopy. Pterostilbene plays an important role in resisting disease in humans and shows more metabolic stability, stronger pharmacological activities, and longer half-life when compared with resveratrol.中文翻译:
从虎杖中发现内生真菌,并通过内生青霉菌将白藜芦醇生物转化为紫草烯。F5