Pluripotent and post‐natal, tissue‐specific stem cells share functional features such as the capacity to differentiate into multiple lineages and to self‐renew, and are endowed with specific cell maintenance mechanism as well as transcriptional and epigenetic signatures that determine stem cell identity and distinguish them from their progeny. Calcium is a highly versatile and ubiquitous second messenger that regulates a wide variety of cellular functions. Specific roles of calcium in stem cell niches and stem cell maintenance mechanisms are only beginning to be explored, however. In this review, I discuss stem cell‐specific regulation and roles of calcium, focusing on its potential involvement in the intertwined metabolic and epigenetic regulation of stem cells.

中文翻译：

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钙调节干细胞。

多能和出生后组织特异性干细胞具有功能特征，例如分化为多种谱系和自我更新的能力，并具有特定的细胞维持机制以及决定干细胞特性和特性的转录和表观遗传学特征。区别于他们的后代。钙是一种高度通用的无处不在的第二信使，可调节多种细胞功能。然而，钙在干细胞壁ches和干细胞维持机制中的特定作用只是开始被探索。在这篇综述中，我将讨论干细胞特有的调节和钙的作用，重点是钙可能参与干细胞的代谢和表观遗传学调控的相互交织。