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Elasticizing tissues for reversible shape transformation and accelerated molecular labeling.
Nature Methods ( IF 48.0 ) Pub Date : 2020-05-18 , DOI: 10.1038/s41592-020-0823-y
Taeyun Ku 1, 2, 3 , Webster Guan 4 , Nicholas B Evans 1, 2 , Chang Ho Sohn 1, 2 , Alexandre Albanese 1 , Joon-Goon Kim 5 , Matthew P Frosch 6 , Kwanghun Chung 1, 2, 4, 7, 8, 9, 10
Affiliation  

We developed entangled link-augmented stretchable tissue-hydrogel (ELAST), a technology that transforms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability simultaneously. ELASTicized tissues are highly stretchable and compressible, which enables reversible shape transformation and faster delivery of probes into intact tissue specimens via mechanical thinning. This universal platform may facilitate rapid and scalable molecular phenotyping of large-scale biological systems, such as human organs.

中文翻译:

弹性组织以实现可逆形状转变和加速分子标记。

我们开发了纠缠链增强可拉伸组织水凝胶(ELAST),这项技术可将组织转化为弹性水凝胶,同时增强大分子可及性和机械稳定性。弹性组织具有高度的拉伸性和可压缩性,可实现可逆的形状转变,并通过机械减薄将探针更快地输送到完整的组织样本中。这个通用平台可以促进大规模生物系统(例如人体器官)的快速且可扩展的分子表型分析。
更新日期:2020-05-18
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