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Directing traffic in the germinal center roundabout.
Nature Immunology ( IF 30.5 ) Pub Date : 2020-05-18 , DOI: 10.1038/s41590-020-0690-9
Jagan R Muppidi 1 , Ulf Klein 2
Affiliation  

B cells undergo iterative rounds of somatic hypermutation and selection for high-affinity antigen binding in the germinal center microenvironment. Two new studies provide insights into the temporal and spatial control mechanisms that act within B cells and follicular dendritic cells to jointly govern B cell differentiation and cell traffic within the GC.

中文翻译:

在生发中心回旋处指挥交通。

B细胞经历轮回的体细胞超突变,并在生发中心微环境中选择高亲和力抗原结合。两项新的研究提供了对B细胞和滤泡树突状细胞内共同控制B细胞分化和GC中细胞运输的时空控制机制的见解。
更新日期:2020-05-18
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