The transcription factor oestrogen receptor alpha (ERα) has long been targeted for therapeutic benefit in cancer, but drug resistance can emerge through a multitude of mechanisms. A study now reveals how the ERα cistrome can become reprogrammed to confer resistance to tamoxifen in breast cancer.

中文翻译：

---

柔韧的ERα病因可逃避治疗。

长期以来，转录因子雌激素受体α（ERα）一直是治疗癌症的靶标，但是耐药性可能通过多种机制出现。现在的一项研究揭示了如何将ERα病史重新编程以赋予乳腺癌对他莫昔芬的抗性。