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Copper-based fluorinated reagents for the synthesis of CF2R-containing molecules (R ≠ F).
Beilstein Journal of Organic Chemistry ( IF 2.7 ) Pub Date : 2020-05-18 , DOI: 10.3762/bjoc.16.92
Louise Ruyet 1 , Tatiana Besset 1
Affiliation  

Over the years, the development of new methodologies for the introduction of various fluorinated motifs has gained a significant interest due to the importance of fluorine-containing molecules in the pharmaceutical and agrochemical industries. In a world eager to eco-friendlier tools, the need for innovative methods has been growing. To address these two challenges, copper-based reagents were developed to introduce CF2H, CF2RF, CF2CH3, CF2PO(OEt)2 and CF2SO2Ph motifs on a broad range of substrates. Copper-based fluorinated reagents have the advantage of being inexpensive and generally in situ generated or prepared in a few steps, which make them convenient to use. In this review, an overview of the recent advances made for the synthesis of fluorinated molecules using copper-based fluorinated reagents will be given.

中文翻译:

铜基氟化试剂,用于合成含CF2R的分子(R≠F)。

多年来,由于含氟分子在制药和农业化学工业中的重要性,开发用于引入各种氟化基序的新方法引起了人们的极大兴趣。在渴望使用环保工具的世界中,对创新方法的需求不断增长。为了应对这两个挑战,开发了铜基试剂以引入CF 2 H,CF 2 R F,CF 2 CH 3,CF 2 PO(OEt)2和CF 2 SO 2在各种基材上的Ph图案。铜基氟化试剂的优点是价格便宜,并且通常在几个步骤中原位生成或制备,这使得它们易于使用。在这篇综述中,将概述使用铜基氟化试剂合成氟化分子的最新进展。
更新日期:2020-05-18
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