The aim of this study was to determine the changes in the pharmacokinetics of meloxicam in goat kids who were castrated following the administration of xylazine. Six goat kids were used for the study. The study was performed in two periods according to a longitudinal study, with a 15‐day washout period between periods. In the first period (Control group), 1 mg/kg meloxicam was administered by i.v. route to kids. In the second period (Castration group), the kids were sedated with 0.3 mg/kg xylazine and castration was performed following meloxicam administration. Plasma meloxicam concentration was analyzed using HPLC‐UV, and pharmacokinetic parameters were calculated by noncompartmental model. In the control group following the administration of meloxicam, mean elimination half‐life (t_1/2ʎz), area under the concentration–time curve (AUC_0−∞), total body clearance (Cl_T), and volume of distribution at steady‐state (V_dss) were 13.50 ± 0.62 hr, 41.10 ± 2.86 hr µg/ml, 24.43 ± 1.75 ml hr⁻¹ kg⁻¹, and 0.45 ± 0.03 L/kg, respectively. In the castration group, the t_1/2ʎz of meloxicam prolonged, AUC_0−∞ increased, and Cl_T and V_dss decreased. In conclusion, the excretion of meloxicam from the body slowed and the t_1/2ʎz was prolonged in the castrated goat kids following xylazine administration. However, there is a need to determine the pharmacodynamics of meloxicam in castrated goat kids.

中文翻译：

---

去势程序对美洛昔康对山羊孩子药代动力学的影响。

这项研究的目的是确定美洛昔康在服用赛拉嗪后被cast割的山羊孩子中药代动力学的变化。六个山羊小孩被用于研究。根据一项纵向研究，研究分两个阶段进行，每个阶段之间有15天的淘汰期。在第一个时期（对照组），通过静脉输注给孩子1 mg / kg美洛昔康。在第二阶段（C割组），给孩子服用0.3 mg / kg的甲苯噻嗪镇静，并在服用美洛昔康后进行cast割。使用HPLC-UV分析血浆美洛昔康浓度，并通过非房室模型计算药代动力学参数。在服用美洛昔康后的对照组中，平均消除半衰期（t _{1/ 2ʎz}），浓度-时间曲线下的面积（AUC0 _-∞），全身清除率（Cl _T）和稳态分布量（V _dss）为13.50±0.62 hr，41.10±2.86 hr µg / ml，分别为24.43±1.75 ml hr ^-1  kg ^-1和0.45±0.03 L / kg。去势组中，美洛昔康的t _{1/ 2ʎz}延长，_{AUC0 -∞}增加，Cl _T和V _dss减少。总之，美洛昔康从体内的排泄速度减慢，t _{1/ 2ʎz}服用甲苯噻嗪后，the割的山羊孩子体内的维生素A延长。但是，有必要确定美洛昔康在cast割的山羊类儿童中的药效学。