High‐level exposure to aflatoxin B1 (AFB1) is known to cause acute liver damage and fatality in animals and humans. The intakes actually causing this acute toxicity have so far been estimated based on AFB1 levels in contaminated foods or biomarkers in serum. The aim of the present study is to predict the doses causing acute liver toxicity of AFB1 in rats and humans by an in vitro–in silico testing strategy.

中文翻译：

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通过体外计算机模拟测试策略预测黄曲霉毒素 B1 对大鼠和人类的急性肝脏毒性。

众所周知，大量接触黄曲霉毒素 B1 (AFB1) 会导致动物和人类急性肝损伤和死亡。迄今为止，实际导致这种急性毒性的摄入量是根据受污染食品中的 AFB1 水平或血清中的生物标志物来估计的。本研究的目的是通过体外计算机模拟测试策略来预测引起大鼠和人类急性肝毒性的 AFB1 剂量。