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Dynamical patterning modules and network motifs as joint determinants of development: Lessons from an aggregative bacterium
Journal of Experimental Zoology-B: Molecular and Developmental Evolution ( IF 2.2 ) Pub Date : 2020-05-17 , DOI: 10.1002/jez.b.22946
Alejandra Guzmán-Herrera 1, 2 , Juan A Arias Del Angel 3, 4, 5 , Natsuko Rivera-Yoshida 1 , Mariana Benítez 3, 4 , Alessio Franci 1
Affiliation  

Development and evolution are dynamical processes under the continuous control of organismic and environmental factors. Generic physical processes, associated with biological materials and certain genes or molecules, provide a morphological template for the evolution and development of organism forms. Generic dynamical behaviors, associated with recurring network motifs, provide a temporal template for the regulation and coordination of biological processes. The role of generic physical processes and their associated molecules in development is the topic of the dynamical patterning module (DPM) framework. The role of generic dynamical behaviors in biological regulation is studied via the identification of the associated network motifs (NMs). We propose a joint DPM–NM perspective on the emergence and regulation of multicellularity focusing on a multicellular aggregative bacterium, Myxococcus xanthus. Understanding M. xanthus development as a dynamical process embedded in a physical substrate provides novel insights into the interaction between developmental regulatory networks and generic physical processes in the evolutionary transition to multicellularity.

中文翻译:

动态模式模块和网络基序作为发展的联合决定因素:来自聚集细菌的教训

发展和进化是在有机体和环境因素不断控制下的动态过程。与生物材料和某些基因或分子相关的通用物理过程为生物体的进化和发展提供了形态模板。与重复出现的网络基序相关的通用动态行为为生物过程的调节和协调提供了时间模板。通用物理过程及其相关分子在开发中的作用是动态模式模块 (DPM) 框架的主题。通过识别相关的网络基序 (NM) 来研究通用动态行为在生物调节中的作用。黄色粘球菌。将M. xanthus发育理解为嵌入在物理基质中的动态过程,为了解发育调节网络与多细胞进化过渡中的一般物理过程之间的相互作用提供了新的见解。
更新日期:2020-05-17
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