OBJECTIVES To explore whether placement of a soft cortical membrane can restore and regenerate the original alveolar ridge contour in deficient sockets. MATERIALS AND METHODS One Beagle dog was used in this proof-of-principle evaluation. In a first intervention, a standardized buccal dehiscence defect was artificially created at the distal roots of the 3rd and 4th mandibular premolars. Four weeks later, following endodontic treatment of the mesial roots, teeth were hemisected and the distal roots were extracted without raising a flap. A cortical membrane (Lamina®, Osteobiol) was placed outside of the bony envelope of the extraction socket to rebuild the buccal bone contour. Afterwards, sockets were filled with a collagen-modified porcine bone graft material (Gen-Os®, Osteobiol) to the level of the surrounding bone height. The socket orifice was closed with a porcine dermal matrix (Derma®). After four months, block specimens containing the socket-sites and remaining roots were retrieved, histologically processed and analyzed. RESULTS Surgery and post-operative healing were uneventful. Histologically, bone formation under the membrane was found, i.e. bony protrusions and ossicles by osteoblasts could be identified. Concomitantly, the membrane showed clear signs of degradation. Bone substitute was well integrated in newly formed bone and resorption of particles was found. CONCLUSION Three major observations were made in the present proof-of-principle study: (i) regeneration of a compromised socket seems possible when applying the presented approach, (ii) the soft cortical membrane was sufficiently stable to allow for the establishment of the contour and to inhibit soft tissue invasion and (iii) the applied xenogenic graft material was undergoing remodelling processes while allowing adequate bone regeneration.

中文翻译：

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应用软皮质膜保护受损的拔牙窝的脊部保护：犬的原理验证评估。

目的探讨放置软皮质膜能否恢复和再生缺损牙槽中的原始牙槽contour轮​​廓。材料和方法一只Beagle犬用于本原理验证评估。在第一个干预中，在第3和第4下颌前磨牙的远端根部人工制造了标准化的颊裂开裂缺损。四周后，在对中根进行牙髓治疗之后，将牙齿半切开，并拔出远侧的根而没有抬起皮瓣。将皮层膜（Lamina®，Osteobiol）放置在拔牙窝的骨膜外，以重建颊骨轮廓。之后，向窝中填充胶原蛋白修饰的猪骨移植材料（Gen-Os®，Osteeobiol）至周围骨高水平。用猪真皮基质封闭窝孔。四个月后，取回包含窝位和剩余根的块状标本，进行组织学处理和分析。结果手术和术后康复均顺利。在组织学上，发现了在膜下的骨形成，即可以识别成骨细胞的骨突起和小骨。同时，膜显示出明显的降解迹象。骨替代物很好地整合在新形成的骨骼中，并且发现了颗粒的吸收。结论在本原理验证研究中，我们得出了三点主要观察结果：（i）当采用本文提出的方法时，似乎有可能再生受损的插座，