The evolutionary healing phenomenon of fractured tibia bone was investigated by comparing the bio-mechanical response of the human tibia following fracture fixation for two ranges of patient ages, when a body weight pressure (BWP) is applied. Three-dimensional finite element models have been developed by adopting the biomechanical characteristics of cortical and trabecular tibia bones, and considering the time-varying callus properties during the healing process for the two patients. The stress and strain levels generated within the fractured tibia bone by the screw tight fit during the assembly process revealed its dependence on the bone stiffness that degrades with age. They have an impact on primary stability of the implants prior to the osseointegration. The gap capacity to resist and allow a gradual BWP load transfer, through the callus for the tibia bone models, was analyzed. In fact, from 10 weeks after surgery, the callus allowed the BWP transfer for young patients, which guarantees sufficient structure stabilization of the fractured tibia. However, an insufficient load was transferred to the fracture gap for the old patient, even beyond 16 weeks, which delayed the bone consolidation

通过比较在施加体重压力（BWP）的两个年龄段的患者年龄后骨折后固定人胫骨的生物力学响应，研究了胫骨骨折的进化愈合现象。通过采用皮质和小梁胫骨的生物力学特性，并考虑了两名患者愈合过程中随时间变化的愈伤组织特性，开发了三维有限元模型。在组装过程中，螺钉拧紧配合在胫骨骨折内产生的应力和应变水平显示出其对随着年龄增长而退化的骨硬度的依赖性。它们对骨整合之前的植入物的基本稳定性有影响。抵抗并允许逐渐的BWP负载转移的间隙容量，通过对骨call的骨us模型，进行了分析。实际上，从术后10周起，愈伤组织允许年轻患者进行BWP转移，从而确保了胫骨骨折的足够结构稳定。然而，即使是超过16周，对于老年患者，也无法将足够的负荷转移到骨折间隙，这延迟了骨固结