Femoropopliteal arteries (FPAs) are subjected to a wide range of deformations, mainly determined by leg movement. FPAs are often affected by atherosclerotic plaque development, presumably influenced by the biomechanics of surrounding tissues. Although abnormal hemodynamics in FPAs appears to be an important factor in driving plaque development, to date it has been investigated in few studies, in which the leg was modeled in either fixed straight or bent configuration. Hence, the current work investigates the impact of leg movement on FPA hemodynamics.

An idealized model of FPA was created to perform moving-boundary computational fluid dynamics analyses. By mimicking hip rotation, knee flexion and complete movement of walking, the hemodynamics was compared between moving- and fixed-boundary models. Moreover, additional features affecting the hemodynamics (e.g. flow-rate curve amplitude, walking speed) were examined.

Significant hemodynamic differences were found between the moving- and fixed-boundary models, with the leg movement inducing higher time-averaged wall shear stress (TAWSS) (up to 66%). The flow-rate amplitude and walking period were the most influential parameters (differences in TAWSS up to 68% and 74%, respectively).

In conclusion, this numerical approach highlighted the importance of considering leg movement to investigate FPA hemodynamics, and it could be employed in future patient-specific analyses.

pop小动脉（FPA）受到多种变形，主要由腿部运动决定。FPA通常受动脉粥样硬化斑块形成的影响，大概受周围组织的生物力学影响。尽管FPA中异常的血流动力学似乎是驱动斑块发展的重要因素，但迄今为止，在很少的研究中已对此进行了研究，在该研究中，以固定的笔直或弯曲形态对腿进行了建模。因此，当前的工作调查了腿部运动对FPA血液动力学的影响。

创建了理想的FPA模型来执行移动边界计算流体动力学分析。通过模拟髋关节旋转，膝盖弯曲和行走的完全运动，比较了运动边界模型和固定边界模型之间的血流动力学。此外，还检查了影响血液动力学的其他特征（例如流速曲线幅度，步行速度）。

在移动边界模型和固定边界模型之间发现了显着的血液动力学差异，腿部运动引起更高的时间平均壁切应力（TAWSS）（高达66％）。流速幅度和步行时间是影响最大的参数（TAWSS中的差异分别高达68％和74％）。

总之，这种数值方法强调了考虑腿部运动来调查FPA血流动力学的重要性，并且可以在以后的针对患者的分析中使用。