Cardiovascular disease (CVD), especially ischemic heart disease and stroke, is the major cause of death worldwide, accounting for more than one third of all deaths annually. Hypertension is the most prevalent and modifiable risk factor of CVD-related deaths. The same is true for obesity, which is currently being recognized as a major global epidemic. The prevalence of obesity in the U.S. has increased dramatically, from 13.4% in 1960 to 36.5% in 2014, with as much as 70.7% of the American adult population being overweight or obese (CDC). Epidemiological studies have shown that obesity predisposes to hypertension and CVD – with the relationship between markers of obesity and blood pressure being almost linear across different populations. In this review, we discuss systemic and pulmonary hypertension in the context of obesity.

心血管疾病（CVD），尤其是缺血性心脏病和中风，是全球范围内的主要死亡原因，每年占死亡总数的三分之一以上。高血压是CVD相关死亡的最普遍和可改变的危险因素。肥胖症也是如此，肥胖症目前被认为是主要的全球流行病。在美国，肥胖症的患病率急剧上升，从1960年的13.4％上升到2014年的36.5％，其中多达70.7％的美国成年人口是超重或肥胖（CDC）。流行病学研究表明，肥胖易患高血压和CVD-在不同人群中，肥胖与血压的标志之间的关系几乎呈线性关系。在这篇综述中，我们讨论了肥胖背景下的全身性和肺动脉高压。