Background and aims

: Visceral adiposity index (VAI), calculated with body mass index, high-density lipoprotein cholesterol, triglyceride and waist circumference, has been proposed as a marker of visceral fat accumulation and dysfunction.

Methods

The impact of VAI on incident nonalcoholic fatty liver disease (NAFLD) in a historical cohort study of 8399 (3773 men and 4626 women) participants. NAFLD was defined as having fatty liver diagnosed by abdominal ultrasonography. We divided the participants into two groups according to sex and into quartiles according to VAI (Q1–4). We calculated VAI using the formulas. Men: VAI = [waist circumference (WC)/39.68 + (1.88 × body mass index [BMI])] × [triglycerides (TG)/1.03] × [1.31/high-density lipoprotein cholesterol (HDL)]; women: VAI = [WC/36.58 + (1.89 × BMI)] × (TG/0.81) × (1.52/HDL). We performed Cox proportional hazard models, adjusting for age, alanine aminotransferase, fasting plasma glucose, systolic blood pressure, alcohol consumption, smoking status and exercise.

Results

During the median 4.5-year follow-up for men and 4.9-year follow-up for women, 1078 participants (737 men and 341 women) developed NAFLD. The 4000 days cumulative incidence rate of NAFLD for men and women were 7.5% and 2.2% in Q1, 14.5% and 4.0% in Q2, 22.3% and 6.7% in Q3 and 33.8% and 16.7% in Q4. The hazard ratios of incident NAFLD in Q4 (VAI: men, > 1.13; women, > 0.83) were 3.69 (95% confidence interval 2.84–4.86, P < 0.001) in men and 4.93 (3.28–7.73, P < 0.001) in women, compared to Q1 (VAI: men, < 0.44; women, < 0.36).

Conclusions

The visceral adiposity index can be a predictor of incident NAFLD.

中文翻译：

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内脏肥胖指数是非酒精性脂肪肝事件的预测指标：一项基于人群的纵向研究。

背景和目标

：内脏肥胖指数 (VAI) 由体重指数、高密度脂蛋白胆固醇、甘油三酯和腰围计算得出，已被提议作为内脏脂肪堆积和功能障碍的标志。

方法

在 8399 名（3773 名男性和 4626 名女性）参与者的历史队列研究中，VAI 对非酒精性脂肪性肝病 (NAFLD) 的影响。NAFLD被定义为腹部超声诊断为脂肪肝。我们根据性别将参与者分为两组，并根据 VAI (Q1-4) 分为四分位数。我们使用公式计算了 VAI。男性：VAI = [腰围 (WC)/39.68 + (1.88 × 体重指数 [BMI])] × [甘油三酯 (TG)/1.03] × [1.31/高密度脂蛋白胆固醇 (HDL)]；女性：VAI = [WC/36.58 + (1.89 × BMI)] × (TG/0.81) × (1.52/HDL)。我们进行了 Cox 比例风险模型，调整了年龄、丙氨酸氨基转移酶、空腹血糖、收缩压、饮酒、吸烟状况和运动。

结果

在男性的中位 4.5 年随访和女性的 4.9 年随访期间，1078 名参与者（737 名男性和 341 名女性）发生了 NAFLD。男女NAFLD 4000天累计发病率第一季度分别为7.5%和2.2%，第二季度为14.5%和4.0%，第三季度为22.3%和6.7%，第四季度为33.8%和16.7%。第四季度发生 NAFLD 的风险比（VAI：男性，> 1.13；女性，> 0.83  ）在男性中为 3.69（95% 置信区间 2.84-4.86，P < 0.001），在男性中为 4.93（3.28-7.73，P  < 0.001）女性，与 Q1 相比（VAI：男性，<0.44；女性，<0.36）。

结论

内脏肥胖指数可以预测 NAFLD 的发生率。