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Chronic high-fat diet affects food-motivated behavior and hedonic systems in the nucleus accumbens of male rats
Appetite ( IF 5.4 ) Pub Date : 2020-10-01 , DOI: 10.1016/j.appet.2020.104739
Danusa Mar Arcego 1 , Rachel Krolow 2 , Carine Lampert 2 , Ana Paula Toniazzo 2 , Emily Dos Santos Garcia 2 , Camilla Lazzaretti 3 , Gustavo Costa 4 , Cecilia Scorza 4 , Carla Dalmaz 1
Affiliation  

Environmental variations can influence eating and motivated behaviors, as well as the brain's feeding circuits to predisposing overweight and obesity. The identification of mechanisms through which a long-term consumption of caloric-dense palatable foods and its association with early life stress can cause neuroadaptations and possible modify motivational behaviors are relevant to elucidate the mechanisms associated with obesity. Here, we investigated the long-term effects of a chronic high-fat diet (HFD), and its interaction with early social isolation on hedonic feeding responses in adult rats. Rats were subjected, or not, to social isolation between postnatal days 21-28 and were fed a control diet or HFD, for 10 weeks post weaning. Hedonic feeding behavior was evaluated during adulthood and parameters related to the dopaminergic, cannabinoid, and opioid systems were measured in the nucleus accumbens. Animals with chronic HFD intake were less motivated to obtain sweet palatable foods. This reduced motivation did not appear to be associated with less pleasure upon tasting sweet food, as no alteration in reactivity to sweet taste was observed. Interestingly, the animals receiving HFD presented decreased immunocontents of the D1 and CB1 receptors, while the stressed group displayed a reduction in dopamine turnover. In summary, chronic HFD causes a significant motivational impairment for sweet palatable foods; these changes may be associated with a decreased dopaminergic and cannabinoid neurotransmission in the nucleus accumbens. In contrast, a brief social isolation during the prepubertal period was unable to alter the behavioral parameters studied but caused a decreased dopaminergic turnover in the nucleus accumbens of adult rats. These findings highlight the importance of long-term HFD exposure on the modulation of hedonic feeding behavior and related neurochemical systems.

中文翻译:

慢性高脂饮食影响雄性大鼠伏核中的食物驱动行为和快感系统

环境变化会影响饮食和动机行为,以及大脑的喂养回路,从而导致超重和肥胖。确定长期食用高热量可口食物及其与早期生活压力的关联可导致神经适应和可能改变动机行为的机制与阐明与肥胖相关的机制有关。在这里,我们研究了慢性高脂肪饮食 (HFD) 的长期影响,及其与早期社会隔离对成年大鼠享乐喂养反应的相互作用。大鼠在出生后第 21-28 天之间接受或不接受社会隔离,并在断奶后 10 周内喂食对照饮食或 HFD。在成年期间评估享乐喂养行为和与多巴胺能相关的参数,在伏隔核中测量了大麻素和阿片类药物系统。长期摄入 HFD 的动物不太愿意获得甜美可口的食物。这种减少的动机似乎与品尝甜食时的愉悦感降低无关,因为没有观察到对甜味的反应性发生变化。有趣的是,接受 HFD 的动物表现出 D1 和 CB1 受体的免疫含量降低,而压力组表现出多巴胺周转的减少。总之,慢性 HFD 会导致对甜味可口食物的显着动机障碍;这些变化可能与伏隔核中多巴胺能和大麻素神经传递的减少有关。相比之下,青春期前短暂的社会隔离无法改变所研究的行为参数,但会导致成年大鼠伏核中多巴胺能转换减少。这些发现强调了长期 HFD 暴露对调节快感进食行为和相关神经化学系统的重要性。
更新日期:2020-10-01
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