Purpose

Colorectal cancer (CRC) is the third most common cancer in the USA. The objective of this study was to compare quality of life (QoL) across long-term colorectal cancer survivors and unaffected matched controls while adjusting for comorbidities.

Methods

The National Cancer Institute (NCI)-funded Colon Cancer Family Registry (CCFR) was used to randomly select and recruit CRC survivors (≥ 5 years from diagnosis) and matched controls for a cross-sectional survey. Nine geographically diverse sites in the USA from the CCFR participated in the study. Telephone interviews were conducted using computer-assisted methods to assess QoL.

Results

A total of 403 cases and 401 controls were included in the final sample. Unadjusted comparison revealed no significant difference between CRC survivors and controls with respect to measures of fatigue, social, emotional, functional, and physical well-being. Multivariate logistic regression revealed that case status had a significant negative influence on colorectal cancer-specific QoL measures. Higher comorbidity indices had a significant negative influence on overall QoL regardless of case status.

Conclusions

Quality of life among long-term CRC survivors is similar to control subjects, with the exception of worse CRC-specific QoL measures. Higher comorbidity indices were independently associated with poor QoL for both cases and controls.

Implications for Cancer Survivors

Survivors and healthcare providers should be aware that long-term QoL is comparable to the general population; however, there is potential that digestive tract-specific issues may persist.

中文翻译：

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长期结直肠癌幸存者的生活质量和合并症的负面影响：基于人群的比较。

目的

大肠癌（CRC）是美国第三大最常见的癌症。这项研究的目的是比较长期结直肠癌幸存者和未受影响的匹配对照组的生活质量（QoL），同时调整合并症。

方法

由美国国家癌症研究所（NCI）资助的结肠癌家庭注册中心（CCFR）随机选择和招募CRC幸存者（诊断后≥5年），并与对照进行配对以进行横断面调查。来自CCFR的美国九个地理位置不同的站点参加了该研究。使用计算机辅助方法进行电话采访以评估QoL。

结果

最终样本中总共包括403个病例和401个对照。未经调整的比较显示，CRC幸存者与对照组之间在疲劳，社交，情感，功能和身体健康方面的测量值无显着差异。多因素logistic回归显示，病例状态对结直肠癌特异性QoL指标有显着负面影响。无论病例状态如何，较高的合并症指数均对总体生活质量产生重大负面影响。

结论

长期CRC生存者的生活质量与对照组相似，只是CRC特异的QoL指标较差。合并症指数越高，病例和对照者的生活质量就越差。

对癌症幸存者的影响

幸存者和医疗保健提供者应意识到，长期生活质量可与普通人群相提并论。但是，可能存在消化道特异性问题。